This is the current focus of my research. Utilizing anisotropic and hybrid nanoparticle architectures to introduce directionality in motion, precisely orienting targeting molecules and directed exertion of force by nanosystems. Anisotropic nanoparticles can be janus hybrids or non-spherical nanoparticles and includes rods, plates, prisms and core-shells. This will lay the basis for nanomotors and nanomachines that can lead to better penetration of solid tumors for therapeutics delivery. Such hybrid multi-surface nanomachines can also simultaneously target multiple abnormal cells in circulation for diagnostics and therapeutic applications.